SSRIs: What They Are, How They Work, and What You Need to Know

When you hear SSRIs, selective serotonin reuptake inhibitors are a class of antidepressants that increase serotonin levels in the brain to improve mood. Also known as antidepressants, they’re among the most prescribed medications for depression, anxiety, and sometimes OCD or PTSD. But not all SSRIs are created equal—some carry hidden risks, especially for your heart, and knowing the difference can keep you safe.

One of the biggest concerns with certain SSRIs is QT prolongation, a heart rhythm issue that can lead to dangerous arrhythmias. Citalopram, an SSRI used for depression and anxiety, has clear dose limits because higher amounts increase this risk. Escitalopram, the more active form of citalopram and also an SSRI, is safer at standard doses but still needs monitoring in older adults or those with heart conditions. These aren’t just side effects—they’re real, measurable dangers backed by clinical studies and FDA warnings.

Why does this matter? Because if you’re taking an SSRI, you might assume they’re all the same. They’re not. Some work better for your type of anxiety. Others are easier on your stomach. A few, like citalopram, need strict dose control. And if you’re on other meds—like antibiotics or heart drugs—the combo could raise your risk even more. You don’t need to stop taking them. You just need to know which one you’re on, why it was chosen, and what to watch for.

Below, you’ll find real-world guides on how these drugs affect your body, what doses are safe, how they compare to other antidepressants, and what to do if you notice unusual symptoms like dizziness, skipped beats, or unexplained fatigue. No fluff. No marketing. Just what you need to stay healthy while taking these meds.